Targeting biomolecules
We are designing luminescent metal complexes and small molecules to target biomolecules and specific structures within cells. These compounds can be used as structural probes for a range of state-of-the-art microscopy techniques, including confocal microscopy and transmission electron microscopy. By careful selection of the chemical and physical properties of the compounds, we are also producing new therapeutic leads.
Nuclear DNA of living cells stained red
Structure of a quadruplex DNA bound complex
Endoplastic reticulum of fixed cells shown yellow through co-staining with a metal complex and a fluorescent antibody